Cell Cycle and Cell Division — Revision Notes
IISER Aptitude Test · Biology
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Key Topics to Revise
10.1 Cell Cycle - Overview and Phases
- Cell cycle is the sequence of events by which a cell duplicates its genome, synthesizes cellular components, and divides into two daughter cells
- Human cells complete one cell cycle in approximately 24 hours, while yeast cells can complete it in 90 minutes
- Cell cycle has two main phases: Interphase (95% duration) and M-phase (5% duration)
10.2 M Phase - Mitosis Detailed
- Mitosis is equational division - chromosome number remains same in daughter cells (2n→2n)
- Four stages: Prophase, Metaphase, Anaphase, Telophase (PMAT sequence)
- Prophase: Chromosome condensation, nuclear envelope breakdown, centriole movement to opposite poles, spindle formation
10.3 Significance of Mitosis
- Growth and development: Increases cell number in multicellular organisms
- Tissue repair and regeneration: Replaces damaged or worn-out cells
- Maintenance of chromosome number: All body cells have identical genetic material
10.4 Meiosis - Reductional Division
- Meiosis is reductional division: diploid (2n) → haploid (n) gametes
- Two consecutive divisions: Meiosis I (reductional) and Meiosis II (equational)
- One round of DNA replication followed by two divisions
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